Adjacent bone changes caused by hemophilic pseudotumor using 3T MRI scan

Objective: This study was to investigate the factors involved in bone changes of hemophilic pseudotumor (HP) in soft tissues and their clinical value. Methods: The study included 32 patients with HP. All lesions were scanned multi-dimensionally with T1 weighted Imaging (WI), T2WI Imaging conventional scan and T2/PD fat suppression (FS) sequences of 3.0T magnetic resonance imaging (MRI). Bone condition was observed in all patients. Four factors on T2WI FS or PDWI FS sequences, including largest transverse diameter (LTD) of HP, the scope of bone wrapped (SOBW) by HP, the distance (D) between HP and bone and the largest longitudinal diameter (LLD) were measured. Results: Among all 32 patients, a total of 39 HPs were detected. Twenty-four lesions had periosteal edema or proliferation. There were significant differences in LLD, D and SOBW between cases with and without periosteal edema or proliferation (P<0.05). Fifteen lesions had marrow edema, and there were significant differences in LLD and SOBW between cases with and without marrow edema (P<0.05). Conclusion: LLD, D and SOBW are important factors involved in bone changes of HP in soft tissues. Abnormal changes of skeleton can be revealed clearly on T2/PD FS sequences, which could provide reliable information for the decision of surgical plan preoperatively.